| 摘要: |
| 聚己内酯-聚乙二醇-聚己内酯(PCL-PEG-PCL)三嵌段共聚物的水溶液,具有低临界溶液温度(LCST),可制备温敏水凝胶,并可作为药物载体应用于生物医学领域。 使用 β-环糊精衍生物作为分子胶囊,在改善疏水性药物的水溶性的同时,提高 PCL-PEG-PCL 水凝胶对疏水性药物的装载和释放能力。 实验中槲皮素作为疏水性药物的模型,由于槲皮素分子与 β-环糊精络合形成微胶囊包装结构,大幅度提高了槲皮素的溶解度;此外槲皮素 / β-环糊精衍生物水溶液中 PCL-PEG-PCL 三嵌段聚合物,也快速溶解形成共混溶液,当温度提高到体温时,迅速变成凝胶状态。 在缓冲溶液中进行了槲皮素药物的释放实验,实现了 PCL-PEG-PCL 水凝胶对疏水性药物的缓释效果,在缓释过程中 β-环糊精衍生物也充当了药物释放载体的作用。 |
| 关键词: 生物降解高分子 温敏水凝胶 药物装载释放 环糊精 |
| DOI： |
| 分类号:TS206; TB487 |
| 基金项目:内蒙古农业大学博士启动基金 |
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| Drug Loading and Release Behavior of Thermosensitive Hydrogel |
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DONG Tungalag, WANG Shuang-shuang, ZHAO Shu-huan, SURINA, LI Meng-ting, JIN Ye
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Inner Mongolia Agricultural University, Hohhot 010018, China
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| Abstract: |
| Water solution of PCL-PEG-PCL triblock copolymer has low critical solution temperature, which can be used to prepare thermosensitive hydrogel and can be used as drug carrier in biomedical field. β-cyclodextrin derivatives were used as molecule capsules, which improve water solubility of hydrophobic drug and improve drug loading and release ability of PCL-PEG-PCL hydrogel to hydrophobic drug. Quercetin was used as model hydrophobic drug in the experiments. The solubility of quercetin was greatly improved because microcapsule packaging structure was formed by complexation between quercetin and β-cyclodextrin; blended solution was also formed by quickly solving of PCL-PEG-PCL triblock copolymer in quercetin/ β-cyclodextrin derivatives water solution, which quickly changed to hydrogel state when temperature rise to human body temperature. Slow releasing experiments of quercetin were carried out in buffered solution, slow releasing effect of hydrophobic drug by PCL-PEG-PCL hydrogels realized, and β-cyclodextrin derivatives also acted as drug carrier in the slow releasing process. |
| Key words: biodegradable polymer thermosensitive hydrogel durg loading cyclodextrin |
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